Eif2ak2 Polyclonal Antibody for Mouse(Mus musculus) | EIAab.comEif2ak2 Polyclonal Antibody for Mouse(Mus musculus)

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Eif2ak2 (Gene name),

Interferon-induced, double-stranded RNA-activated protein kinase (Protein name ), E2AK2_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Eif2ak2(Pkr;Prkr;Tik);

Protein name:

Interferon-induced, double-stranded RNA-activated protein kinase;

Alternative:

Interferon-inducible RNA-dependent protein kinase;Eukaryotic translation initiation factor 2-alpha kinase 2(eIF-2A protein kinase 2);Protein kinase RNA-activated(PKR);P1/eIF-2A protein kinase;2.7.10.2;Tyrosine-protein kinase EIF2AK2);Serine/threonine-protein kinase TIK;p68 kinase;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Homodimer. Interacts with DNAJC3 and STRBP (By similarity). Forms a complex with FANCA, FANCC, FANCG and HSP70.

Function:

Following activation by double-stranded RNA in the presence of ATP, the kinase becomes autophosphorylated and can catalyze the phosphorylation of the translation initiation factor EIF2S1, which leads to an inhibition of the initiation of protein synthesis. Double-stranded RNA is generated during the course of a viral infection. In adddition to serine/threonine-protein kinase activity, also has tyrosine-protein kinase activity: phosphorylates CDK1 upon DNA damage. CDK1 phosphorylation triggers CDK1 polyubiquitination and subsequent proteolysis, thus leading to G2 arrest.

Subcellular Location:

N/A

Protein Attributes:

Sequence length:

515

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

515:

AEWRNISEKK | KRNTC

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Mm.378990

SMR:

Q03963

String:

Q03963

KEGG:

mmu:19106

Pfam:

PF00035

Uniprot:

Q03963

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ELISA Kit for Mouse Interferon-induced, double-stranded RNA-activated protein kinase

Cat.:

E1135r

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96T

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ELISA Kit for Mouse Interferon-induced, double-stranded RNA-activated protein kinase

Cat.:

E1135h

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ELISA Kit for Mouse Interferon-induced, double-stranded RNA-activated protein kinase

Cat.:

E1135m

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CLIA Kit for Mouse Interferon-induced, double-stranded RNA-activated protein kinase

Cat.:

U1135h

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96T

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CLIA Kit for Mouse Interferon-induced, double-stranded RNA-activated protein kinase

Cat.:

U1135m

Price:

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MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Mouse Interferon-induced, double-stranded RNA-activated protein kinase

Cat.:

U1135r

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MSDS:

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Packing:

96T

Polyclonal Antibody for Mouse Interferon-induced, double-stranded RNA-activated protein kinase

Cat.:

P1135Rb-r

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40ug/0.2ml

Polyclonal Antibody for Mouse Interferon-induced, double-stranded RNA-activated protein kinase

Cat.:

P1135Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse Interferon-induced, double-stranded RNA-activated protein kinase

Cat.:

P1135Rb-h

Price:

Please sign in first.

Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse Interferon-induced, double-stranded RNA-activated protein kinase

Protein for Mouse Interferon-induced, double-stranded RNA-activated protein kinase

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"TIK, a novel serine/threonine kinase, is recognized by antibodies directed against phosphotyrosine."
Icely P.L. , Gros P. , Bergeron J.J.M. , Devault A. , Afar D.E.H. , Bell J.C.
J. Biol. Chem.266:16073-16077(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

"Identification of double-stranded RNA-binding domains in the interferon-induced double-stranded RNA-activated p68 kinase."
Feng G.S. , Chong K. , Kumar A. , Williams B.R.G.
Proc. Natl. Acad. Sci. U.S.A.89:5447-5451(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Mammary carcinoma.
3.

"Mechanism of interferon action: structure of the mouse PKR gene encoding the interferon-inducible RNA-dependent protein kinase."
Tanaka H. , Samuel C.E.
Proc. Natl. Acad. Sci. U.S.A.91:7995-7999(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
strain: DBA/2J.
tissue: Liver.
4.

"Sequence of the murine interferon-inducible RNA-dependent protein kinase (PKR) deduced from genomic clones."
Tanaka H. , Samuel C.E.
Gene153:283-284(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
strain: DBA/2J.
tissue: Liver.
5.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: C57BL/6J.
tissue: Skin.
6.

"PKR stimulates NF-kappaB irrespective of its kinase function by interacting with the IkappaB kinase complex."
Bonnet M.C. , Weil R. , Dam E. , Hovanessian A.G. , Meurs E.F.
Mol. Cell. Biol.20:4532-4542(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH IKBKB
7.

"Nucleophosmin interacts with and inhibits the catalytic function of eukaryotic initiation factor 2 kinase PKR."
Pang Q. , Christianson T.A. , Koretsky T. , Carlson H. , David L. , Keeble W. , Faulkner G.R. , Speckhart A. , Bagby G.C.
J. Biol. Chem.278:41709-41717(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NPM1
8.

"Double-stranded RNA deaminase ADAR1 increases host susceptibility to virus infection."
Nie Y. , Hammond G.L. , Yang J.H.
J. Virol.81:917-923(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ADAR
9.

"PKR acts early in infection to suppress Semliki Forest virus production and strongly enhances the type I interferon response."
Barry G. , Breakwell L. , Fragkoudis R. , Attarzadeh-Yazdi G. , Rodriguez-Andres J. , Kohl A. , Fazakerley J.K.
J. Gen. Virol.90:1382-1391(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN SFV RESTRICTION
10.

"An antiviral response directed by PKR phosphorylation of the RNA helicase A."
Sadler A.J. , Latchoumanin O. , Hawkes D. , Mak J. , Williams B.R.
PLoS Pathog.5:E1000311-E1000311(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH DHX9
11.

"Protein kinase R contributes to immunity against specific viruses by regulating interferon mRNA integrity."
Schulz O. , Pichlmair A. , Rehwinkel J. , Rogers N.C. , Scheuner D. , Kato H. , Takeuchi O. , Akira S. , Kaufman R.J. , Reis e Sousa C.
Cell Host Microbe7:354-361(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
12.

"Phosphorylation of the NFAR proteins by the dsRNA-dependent protein kinase PKR constitutes a novel mechanism of translational regulation and cellular defense."
Harashima A. , Guettouche T. , Barber G.N.
Genes Dev.24:2640-2653(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
13.

"Double-stranded RNA-activated protein kinase regulates early innate immune responses during respiratory syncytial virus infection."
Minor R.A. , Limmon G.V. , Miller-DeGraff L. , Dixon D. , Andrews D.M. , Kaufman R.J. , Imani F.
J. Interferon Cytokine Res.30:263-272(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
14.

"Protein kinase R is responsible for the phosphorylation of eIF2alpha in rotavirus infection."
Rojas M. , Arias C.F. , Lopez S.
J. Virol.84:10457-10466(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
15.

"Role of PKR and Type I IFNs in viral control during primary and secondary infection."
Nakayama Y. , Plisch E.H. , Sullivan J. , Thomas C. , Czuprynski C.J. , Williams B.R. , Suresh M.
PLoS Pathog.6:E1000966-E1000966(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN LCMV RESTRICTION
16.

"Protein kinase R is a novel mediator of CD40 signaling and plays a critical role in modulating immunoglobulin expression during respiratory syncytial virus infection."
Thakur S.A. , Zalinger Z.B. , Johnson T.R. , Imani F.
Clin. Vaccine Immunol.18:2060-2066(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
17.

"Novel insights in the interplay between inflammation and metabolic diseases: a role for the pathogen sensing kinase PKR."
Marsollier N. , Ferre P. , Foufelle F.
J. Hepatol.54:1307-1309(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
18.

"Double-stranded RNA-activated protein kinase is a key modulator of insulin sensitivity in physiological conditions and in obesity in mice."
Carvalho-Filho M.A. , Carvalho B.M. , Oliveira A.G. , Guadagnini D. , Ueno M. , Dias M.M. , Tsukumo D.M. , Hirabara S.M. , Reis L.F. , Curi R. , Carvalheira J.B. , Saad M.J.
Endocrinology153:5261-5274(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH IRS1
19.

"Regulation of actin dynamics by protein kinase R control of gelsolin enforces basal innate immune defense."
Irving A.T. , Wang D. , Vasilevski O. , Latchoumanin O. , Kozer N. , Clayton A.H. , Szczepny A. , Morimoto H. , Xu D. , Williams B.R. , Sadler A.J.
Immunity36:795-806(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH GSN
20.

"Novel role of PKR in inflammasome activation and HMGB1 release."
Lu B. , Nakamura T. , Inouye K. , Li J. , Tang Y. , Lundbaeck P. , Valdes-Ferrer S.I. , Olofsson P.S. , Kalb T. , Roth J. , Zou Y. , Erlandsson-Harris H. , Yang H. , Ting J.P. , Wang H. , Andersson U. , Antoine D.J. , Chavan S.S. , more...
Nature488:670-674(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH NLRP3;AUTOPHOSPHORYLATION
21.

"PKR regulates proliferation, differentiation and survival of murine hematopoietic stem/progenitor cells."
Liu X. , Bennett R.L. , Cheng X. , Byrne M. , Reinhard M.K. , May W.S. Jr.
Blood121:3364-3374(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
22.

"The protein kinase PKR is critical for LPS-induced iNOS production but dispensable for inflammasome activation in macrophages."
He Y. , Franchi L. , Nunez G.
Eur. J. Immunol.43:1147-1152(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
23.

"Activation of double-stranded RNA-activated protein kinase (PKR) by interferon-stimulated gene 15 (ISG15) modification down-regulates protein translation."
Okumura F. , Okumura A.J. , Uematsu K. , Hatakeyama S. , Zhang D.E. , Kamura T.
J. Biol. Chem.288:2839-2847(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ISGYLATION
24.

"Blocking the eIF2? kinase (PKR) enhances positive and negative forms of cortex-dependent taste memory."
Stern E. , Chinnakkaruppan A. , David O. , Sonenberg N. , Rosenblum K.
J. Neurosci.33:2517-2525(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
25.

"Solution structure of the first and second DSRM domain in interferon-induced, double-stranded RNA-activated protein kinase."
RIKEN structural genomics initiative (RSGI)
Submitted (2005-11) to the PDB data bank

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 1-171

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